Literature summary extracted from

van Beilen, J.; Blohmke, C.J.; Folkerts, H.; de Boer, R.; Zakrzewska, A.; Kulik, W.; Vaz, F.M.; Brul, S.; Ter Beek, A.
RodZ and PgsA play intertwined roles in membrane homeostasis of Bacillus subtilis and resistance to weak organic acid stress (2016), Front. Microbiol., 7, 1633 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.8.5	Bacillus subtilis	P46322	-	-
2.7.8.5	Bacillus subtilis 168	P46322	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.8.5	pgsA	-	Bacillus subtilis

General Information

EC Number	General Information	Comment	Organism
2.7.8.5	physiological function	the genes encoding cell shape determination protein Rodz and PgsA are co-transcribed and both a RodZ mutant and a conditional PgsA mutant, under conditions of minimal PgsA expression, are sensitive to sorbic and acetic acid. Both strains display a severely altered membrane composition. Compared to the wild-type strain, phosphatidylglycerol and cardiolipin levels are lowered and the average acyl chain length is elongated. Induction of RodZ expression from a plasmid in the mutant leads to no recovery of weak acid susceptibility comparable to wild-type levels. PgsA overexpression in the same mutant partly restores sorbic acid susceptibility and fully restores acetic acid sensitivity. A construct containing both RodZ and PgsA as on the genome leads to some restored growth as well	Bacillus subtilis

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Release 2023.1 (January 2023)